BINAPHANE-Catalyzed Asymmetric Synthesis of trans-β-Lactams from Disubstituted Ketenes and N-Tosyl Arylimines
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https://figshare.com/articles/dataset/BINAPHANE_Catalyzed_Asymmetric_Synthesis_of_i_trans_i_Lactams_from_Disubstituted_Ketenes_and_i_N_i_Tosyl_Arylimines/2533681
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The development of a BINAPHANE-catalyzed formal [2 + 2]-cycloaddition of disubstituted ketenes and inexpensive N-tosyl arylimines that provides access to a variety of highly substituted β-lactams (16 examples) is described. The BINAPHANE catalytic system displays moderate to excellent enantioselectivity (up to 98% ee) and high diastereoselectivity in most cases, favoring formation of the trans-diastereomer (13 examples with dr ≥ 90:10).
创建时间：
2016-02-21
