Iridium(III)-Catalyzed C–H Amidation of Nitrones with Dioxazolones

Various amidated nitrones were efficiently achieved through Ir­(III)-catalyzed direct C–H amidation of nitrones with good to excellent yields and tolerance of broad functional groups. This reaction smoothly proceeded at room temperature in the absence of acid or base in a short reaction time. Carbon dioxide was generated as the sole byproduct, thus providing an environmentally benign amidation process. The title products could be efficiently transformed to substituted benzisoxazoline.