Gene expression in drug resistant and circulating tumor cell cultured H460 or A549 cells Overall design: mRNA expression profiles of 2-dimensionally cultured and circulating tumor cell cultured H460 a
aCGH of control cells not subjected to PDT (Parental), cells subjected to 10 sequential PDT treatments (10G) and 10G cells inoculated in immunosuppressed mice; the induced tumors were subcultured by e
The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an elusive drug target. Her
Tetracyclines (TCs) are an important class of antibiotics threatened by an emerging new resistance mechanismenzymatic inactivation. These TC-inactivating enzymes, also known as tetracycline destructa
Richter’s Transformation (RT) is a poorly understood and fatal progression of chronic lymphocytic leukemia (CLL) manifesting histologically as diffuse large B-cell lymphoma. PRMT5 is implicated in lym
