Characterization of Pancreatic Adenocarcinoma Patients Using NGS

In this study, we whole genome sequenced tumor/normal pairs from three pancreatic adenocarcinoma patients to separately characterize each patient with respect to somatic alterations. For 2 patients for whom tumor RNA was available, we also performed RNA sequencing to evaluate gene expression changes. While additional sequencing is needed to improve our understanding of the disease, the information acquired from this study contributes to our knowledge base on pancreatic cancer and helps to establish a foundation for identifying and developing more efficacious treatments for patients.]]>
Inclusion criteria: patients had to be ≥ 18 years of age and provided signed informed consent. These patients included those with a pathologic or clinical diagnosis of a pancreatic malignant neoplasm, or who were undergoing a medically indicated procedure to obtain tissue or to resect their pancreatic tumor. Other eligibility criteria included: Karnofsky performance status (PS) ≥ 80%, life expectancy > 3 months, baseline laboratory data indicating acceptable bone marrow reserve, liver, and renal function.]]>
This study was carried out using samples collected between 2010 and 2011. The research was performed between 2010 and 2012.]]>