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TAG Synthesis and Oxidation Activated by YAP/TEAD Confers ROS Resistance in Cancer Stem Cells

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE248327
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RNA-seq analysis revealed CSCs upregulated in TAG synthesis enzymes, such as ACSL1/4, LPIN2, DGAT1/2, and PNPLA3, and the anti-ferroptosis arsenal, GPX4, all of which were relevant to CSC radioresistance, sphere formation, and tumor initiation. Compare the TAG synthesis pathway in adherent culture and spheroid culture (CSCs). The related protein expression were inhibited bu ues inhibitor or shRNA.
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2024-01-01
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