Transcriptional responses of human synovial fibroblasts to TNF and IL-17A over time (RNA-seq Data 1). Transcriptional responses of human synovial fibroblasts to TNF and IL-17A over time (RNA-seq Data 1)

The combination of TNF and IL-17A has synergistic effects on the transcription of genes encoding chemokines and cytokines. Overall design: Human fibroblasts derived from individual with rheumatoid arthritis or osteoarthritis were stimulated with TNF or TNF and IL-17A and gene expression was assayed with RNA-seq. RNA-seq Data 1 (n=175): 7 synovial fibroblast cell lines from patient tissues, 9 time points (0, 2, 4, 6, 8, 10, 12, 18, and 24 hours), 3 stimulations (TNF (1 ng/mL); TNF (1 ng/mL) and IL-17A (1 ng/mL); TNF (1 ng/mL) and IL-17A (10 ng/mL)). --------------------------------------------------------------- Authors state "We don't have the required patient consents to deposit the raw sequencing reads." Thus, this dataset is incomplete.