SARS-CoV-2 mutational trajectories dataset

This dataset contains mutation frequency data derived from in vitro evolution experiments of the SARS-CoV-2 spike receptor-binding domain (RBD), conducted under low-stringency (LSS) and high-stringency (HSS) selection pressures. The data capture position-specific mutation distributions and frequencies across multiple rounds of selection and across several RBD variants. These experiments were designed to assess how laboratory-driven evolution parallels the natural evolution of SARS-CoV-2, particularly in the context of ACE2 receptor binding—the critical first step in viral infection.