Mutations in the INF2 gene, a formin associated with controlled actin polymerization, have been identified as a causative factor in human kidney degenerative disease.. null

Mutations in the INF2 gene, a formin associated with controlled actin polymerization, have been identified as a causative factor in human kidney degenerative disease. Pathogenic mutations in INF2 result in its constitutive activation. Our RNA-seq project aims to identify differentially expressed genes in renal cells that express pathogenic INF2. This analysis involves comparing the transcriptomes of cells expressing pathogenic INF2 with those expressing wild-type INF2, as well as with the transcriptome of control cells. This approach will provide valuable insights into the impact of pathogenic INF2 on gene expression and could shed light on the mechanism of INF2-linked kidney degenerative disease.