MOESM1 of Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes

Additional file 1. PAPA scores derived from random sampling of sequence variant combinations for proteins with high-scoring PrLDs. For all proteins with a moderately high-scoring PrLD (PAPA> 0.0) and at least one single-amino acid variant, the minimum and maximum aggregation propensity scores obtained from randomly sampling PrLD sequence variants, along with the corresponding reference sequence score, are indicated (see Methods for a complete description of sequence variant calculations).