Adult-onset loss of hepatocyte growth hormone receptor (GHR) signaling increases steatosis, associated with enhanced glucokinase activity, de novo lipogenesis (DNL) and pathway selective hepatic insulin resistance

RNA-seq analysis of livers from control mice, mice with adult onset, hepatocyte-specific GH receptor (GHR) deficiency, and GHR-deficient mice combined with IGF1 expression or expression of constitutively active ('CA') STAT5b. This dataset is part of a large study showing that adult-onset loss of hepatocyte GHR signaling increases steatosis, associated with enhanced glucokinase activity, de novo lipogenesis (DNL) and pathway selective hepatic insulin resistance. Overall design: We analyzed total RNA from male livers (6 mice/group) from GHR intact-control mice and adult-onset, specific GHR knockdown mice, without (aHepGHRkd) or with hepatic reconstitution of IGF1 (aHepGHRkd + 2.0*E11 AAV8-TBGp-rIGF1) or STAT5bCA (aHepGHRkd + 0.75*E11 AAV8-TBGp-STAT5bCA)