Crystal structure of the SIRT1 catalytic domain bound to NAD and an EX527 analog
收藏Protein Data Bank Japan2023-09-20 更新2026-03-21 收录
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Crystal structure of the SIRT1 catalytic domain bound to NAD and an EX527 analog Descriptor: (6S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide, NAD-dependent protein deacetylase sirtuin-1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Zhao, X, Allison, D, Condon, B, Zhang, F, Gheyi, T, Zhang, A, Ashok, S, Russell, M, Macewan, I, Qian, Y, Jamison, J.A, Luz, J.G. Deposit date: 2012-11-28 Release date: 2013-01-23 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The 2.5 angstrom crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition. J.Med.Chem., 56, 2013
创建时间：
2012-11-28
