Crystal structure of SARS CoV-2 3CL protease in complex with GSK4365096A

Crystal structure of SARS CoV-2 3CL protease in complex with GSK4365096A Descriptor: 3C-like proteinase nsp5, N-[(benzyloxy)carbonyl]-4-fluoro-L-phenylalanyl-N-[(2S,3Z)-1-[(2S)-oxolan-2-yl]-3-(2-oxooxolan-3-ylidene)propan-2-yl]-L-leucinamide Authors: Concha, N.O, Williams, S.P. Deposit date: 2023-10-09 Release date: 2024-03-13 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement. Bioorg.Med.Chem., 100, 2024