Changes in pre-mRNA splicing are associated with the metastatic phenotype in breast cancer

ChEBI2010-06-08 更新2026-07-21 收录

癌症转移机制

RNA剪接调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-21994 数据链接链接失效反馈

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Changes in pre-mRNA splicing are associated with the metastatic phenotype in breast cancer

创建时间：

2010-06-08

shRNAi profiling of human MDA-MB-231 cells expressing anti-p53 (shp53) short-hairpin RNAs treated with TFGbeta or control

癌症转移机制

转录组功能分析

TGFβ ligands act as tumor suppressors in early stage tumors but are paradoxically diverted into potent prometastatic factors in advanced cancers. The molecular nature of this switch remains enigmatic.

NIAID Data Ecosystem30

Chromodomain Helicase/ATPase DNA-Binding Protein 1-Like Gene (CHD1L) Expression and Implications for Invasion and Metastasis of Breast Cancer

癌症转移机制

肿瘤治疗靶点

BackgroundChromodomain helicase/ATPase DNA-binding protein 1-like gene (CHD1L), also known as ALC1 (amplified in liver cancer 1 gene), is a new oncogene amplified in many solid tumors. Whether this ge

Figshare2016-01-15 更新00

Periostin+ stromal cells guide lymphovascular invasion by cancer cells [DSP]

癌症转移机制

肿瘤微环境分析

Cancer cell dissemination to sentinel lymph nodes associates with poor patient outcomes, particularly in breast cancer. The process by which cancer cells egress from the primary tumor upon interfacing

NIAID Data Ecosystem00

RNA sequencing of GLO1-depleted MDA-MB-231 breast cancer cells

癌症转移机制

GLO1基因敲低表达谱

We reported the expression of a pro-metastatic signature in GLO1-depleted MDA-MB-231 cells compared to control. Overall design: RNA sequencing was performed on 3 biological replicates of 2 clones of G

NIAID Data Ecosystem00

Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion

癌症转移机制

微流控细胞分析

Metastasis, the leading cause of cancer-related deaths, involves a complex cascade of events, including extravasation. Despite extensive research into metastasis, the mechanisms underlying extravasati

NIAID Data Ecosystem00

Changes in pre-mRNA splicing are associated with the metastatic phenotype in breast cancer

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