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Contribution of ShkA dysregulation to the cdG0 phenotype

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NIAID Data Ecosystem2026-03-11 收录
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https://www.omicsdi.org/dataset/pride/PXD012739
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The ShkA-ShpA-TacA phosphorelay regulates stalk biogenesis and G1-S phase transition in Caulobacter crescentus. Histidine kinase activity of ShkA is c-di-GMP dependent and a strain lacking c-di-GMP (cdG0) shows a number of phenotypic aberrations. In this project, we aim at disentangling the contribution of ShkA-ShpA-TacA pathway dysregulation to the cdG0 phenotype by profiling the proteomes of mutants that constitutively activate or deactivate TacA target gene expression.
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2019-12-16
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