Estrogen has vascular protective effects in premenopausal women and in women under 60 receiving hormone replacement therapy. However, estrogen also increases risks of breast and uterine cancers and of
Peroxisome proliferator-activated receptor γ (PPARγ) plays a major role in adipogenesis. PPARγ binds to DNA as a heterodimer with retinoid X receptor (RXR), and PPARγ-RXR can be activated by ligands s
The B-cell receptor (BCR) signaling is crucial for the pathophysiology of most leukemias and lymphomas originated from mature B lymphocytes and has emerged as a new therapeutic target, especially for
