Asymmetric Construction of Spiro[thiopyranoindole-benzoisothiazole] Scaffold via a Formal [3 + 3] Spiroannulation
收藏NIAID Data Ecosystem2026-03-08 收录
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资源简介：
An enantioselective formal thio[3 + 3] spiroannulation reaction of indoline-2-thiones to 1-azadienes has been developed by the use of a quinine-derived bifunctional tertiary amine-thiourea catalyst, which furnished a series of optically active spiro[thiopyranoindole-benzoisothiazole] heterocycles with a spiro quaternary C–N/C–S stereogenic centers in high yields with good to excellent diastereo- and enantioselectivities.
创建时间：
2016-02-13
