BackgroundNon-motor symptoms are common in Parkinson’s disease (PD) and can even be used as part of the supportive criteria for diagnosis. Chronic inflammation is involved in every stage of PD. Disord
Sorted CD45⁺ meningeal immune cells from dorsal root ganglia (DRGs) were obtained and processed for droplet-based single-cell RNA sequencing using the 10x Genomics Chromium platform. Single-cell suspe
Sequencing of TRPV1+ neurons in jugular-nodose complex (JNC) in a mouse model of air pollution-exacerbated allergic inflammation. Overall design: TRPV1-cre/wt::tdTomato-fl/wt mice were sensitized via
3D viSNE representation of microglial modules: DAM (Red) and Homeostatic (Black) genes identified by single-cell RNAseq mapped to WGCNA modules. (HTML 3818 kb)
Functional networks were studied by importing Entrez Gene IDs of 14 up-regulated and 2 down-regulated cytokines in IL-1β/TNF-α-activated human astrocytes into the core analysis tool of IPA. They are l
