Integrative analysis of differential circular RNA and long noncoding RNA profiles and associated competing endogenous RNA networks in esophageal squamous cell carcinoma

We constructed a competing endogenous RNA (ceRNA) network of ESCC based on the bovementioned pathways. Our findings provide important insight into the role of lncRNAs and circRNAs in ESCC; the differentially expressed lncRNAs and circRNAs may represent potential targets for ESCC diagnosis and therapy. Overall design: We performed a comprehensive analysis of the expression of RNAs, lncRNAs, and circRNAs by RNA-seq in esophageal squamous cell carcinoma