BIOGRID CURATED DATA FOR IZH2 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for IZH2 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Plasma membrane receptor for plant antifungal protein, osmotin; involved in zinc ion homeostasis, apoptosis; negatively regulates ZRT1 and other functionally divergent genes through CCCTC promoter motif (IzRE); modulates FET3 activity in iron-independent manner; affects gene expression by influencing balance of competition between Msn2p/Msn4p and Nrg1p/Nrg2p for binding to the IzRE; transcription regulated by Zap1p, zinc, fatty acid levels; similar to mammalian adiponectins

蛋白-蛋白、遗传和化学相互作用数据集，针对酵母菌（Saccharomyces cerevisiae (S288c)）中的IZH2，由BioGRID（https://thebiogrid.org）编纂；定义：植物抗真菌蛋白、渗透素受体，位于质膜上；参与锌离子稳态和细胞凋亡过程；通过CCCTC启动子基序（IzRE）负调控ZRT1及其他功能分化基因；以非铁依赖的方式调节FET3活性；通过影响Msn2p/Msn4p与Nrg1p/Nrg2p对IzRE结合的竞争平衡来调控基因表达；转录受Zap1p、锌和脂肪酸水平调节；与哺乳动物的脂联素类似。