Comparative transcriptomic study of skeletal muscles response to muscular dystrophy with myositis

Muscular dystrophy with myositis (mdm) is a severe degenerative muscle disease arising from a spontaneous mutaton at the N2A-PEVK junction of titin protein. The affected mice show a complex disease phenotype, and more organism-wide spread response compared to other myopathies. The project objectives focus on understanding the response pattern of different skeletal muscles to mdm. Examine the transcriptomic response of mdm affected skeletal muscle compared to wildype in the B6C3Fe a/a-Ttnmdm/J +/+ mice伴肌炎的肌营养不良症（Muscular dystrophy with myositis, mdm）是一种因肌联蛋白（titin）N2A-PEVK连接区域发生自发突变而引发的重度退行性肌肉疾病。患病小鼠表现出复杂的疾病表型，且相较于其他肌病，呈现出更广泛的全身病理扩散响应。本项目旨在阐明不同骨骼肌对mdm的响应模式，具体内容为在B6C3Fe a/a-Ttnmdm/J +/+小鼠中，对比受mdm影响的骨骼肌与野生型（wild type）骨骼肌的转录组响应（transcriptomic response）。