Characteristics of the hereditary non-polyposis CRC and control groups studied. Data on Lynch syndrome families and controls were published previously [16].

N, number of subjects; SD, standard deviation; M, male; F, female.1Cancer: Individuals affected with a LS-associated cancer: CRC and/or cancer of the endometrium, ovary, stomach, small bowel, hepatobiliary tract, pancreas, upper uro-epithelial tract or brain.2Controls include non-carriers from LS families (n = 144) and unrelated cancer-free controls (n = 90).3Kruskal-Wallis rank sum test.