Adolescent exposure to AB-FUBINACA in female mice alters mRNA expression in the mPFC

C57BL/6J mice were treated from post-natal day 35 to 49 with increasing doses of AB-FUBINACA (PND 35-39: 1 mg/kg, PND 40-44: 1.5 mg/kg, and PND 45- 49: 2 mg/kg). Behavioral long-term effects were analyzed 20 days after the end of the treatment in both sexes. To carry out biochemical studies, brain samples were collected as required on each technique, 24 hours after the last behavioral test.