Effect of topiramate on body-, liver- and fat weights of obese/insulin resistant rats.

Effect of topiramate (40, 100 mg/kg; TPM40, TPM100) on body weight (BW) and liver weight (LW)/−, visceral fat weight (VFW)/− and epididymal fat weight (EFW)/−BW ratio of obese/insulin resistant rats fed high fat and high fructose diet [HFFD] for 10 weeks. Values are means (± S.D.) of 10 animals. Treatments were administered once daily for 2 weeks. As compared with normal control (*), and HFFD (†) groups (one-way ANOVA followed by Tukey-Kramer Test), P