Replication Data for: Mediterranean and low-fat diets are equally effective in MASLD resolution at 12 weeks regardless of PNPLA3 genotype: A randomized controlled trial

250 MASLD adults with BMI more than 25 kg/m2 were randomized to a 12-week moderately hypocaloric MD or LFD intervention. Individuals with excess alcohol intake and other etiologies of steatosis were excluded. Subjects were genotyped for PNLPA3 single nucleotide polymorphism. Anthropometric measures, blood tests, and liver assessments (controlled-attenuation parameter [CAP] and liver stiffness measurement [LSM]) were conducted at baseline and follow-up. Essential food items were provided, and adherence was tracked using validated questionnaires. Primary outcome was CAP, analyzed using linear mixed models adjusted for age and metabolic syndrome.