Crystal structure of the TIR domain from human SARM1 in complex with 2AD

Crystal structure of the TIR domain from human SARM1 in complex with 2AD Descriptor: Sterile alpha and TIR motif-containing protein 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(8-oxidanylidene-7~{H}-2,7-naphthyridin-2-yl)oxolan-2-yl]methyl hydrogen phosphate Authors: Shi, Y, Ve, T. Deposit date: 2021-06-21 Release date: 2022-03-23 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Mol.Cell, 82, 2022