p-STAT5 dimerizes

Phosphorylated STAT5A and STAT5B form homodimers and heterodimers in the cytosol (Gaffen et al. 1996, Rosenthal et al. 1997, also inferred from mouse homologs). Phosphorylation of a critical tyrosine residue in the SH domain (Y694 in STAT5A and Y699 in STAT5B) and intramolecular interactions between hydrophobic residues in the SH domain are required for dimerization (inferred from mouse homologs).

磷酸化的STAT5A和STAT5B在细胞质中形成同源二聚体和异源二聚体（参见Gaffen等人，1996年；Rosenthal等人，1997年，亦从小鼠同源基因推断）。关键酪氨酸残基（STAT5A中的Y694和STAT5B中的Y699）的磷酸化以及SH结构域中疏水性残基之间的分子内相互作用对于二聚化是必需的（从小鼠同源基因推断）。