Germline and Somatic Disruption of DLG2 in Neuroblastoma

Data suggest that DLG2 functions as a human neuroblastoma suppressor gene Keywords: aCGH To discover genetic events that might be involved in the initiation of neuroblastoma tumorigenesis, we performed a genome-wide scan for DNA copy number abnormalities in the germline and tumor DNAs from ten patients with neuroblastoma and complex congenital abnormalities using a customized high-resolution BAC array-based comparative genomic hybridization (aCGH) platform.