The PNUTS phosphatase complex controls transcription pause release
收藏NIAID Data Ecosystem2026-05-02 收录
官方服务：
资源简介：
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
应用场景：
创建时间：
2024-12-02
相关数据集
A PP2A-Integrator complex fine-tunes transcription by opposing CDK9 [ChIP-seq]
Gene expression by RNA Polymerase II (RNAPII) is tightly controlled by Cyclin-dependent kinases (CDKs) at discrete checkpoints during the transcription cycle. The RNAPII pausing checkpoint, engaged af
NIAID Data Ecosystem100
BRD4 loading at the transcription start site mediates pause-release and underlies the disproportionate transcriptional response to BET bromodomain inhibition [GRO-Seq]. Homo sapiens
BET bromodomain inhibition (BETi) abrogates cancer cell growth by disrupting oncogenic gene expression. BRD4 loading at enhancers has been suggested to mediate pause-release and underlie the selective
NIAID Data Ecosystem80
SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia [ChIP-Seq]. SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia [ChIP-Seq]
Histone methyltransferase SETD1A is critical for acute myeloid leukemia (AML) cell survival, but the molecular mechanism driving SETD1A gene regulation remains elusive. To delineate the role of SETD1A
NIAID Data Ecosystem60
BRD4 loading at the transcription start site mediates pause-release and underlies the disproportionate transcriptional response to BET bromodomain inhibition [RNA-Seq]
BET bromodomain inhibition (BETi) abrogates cancer cell growth by disrupting oncogenic gene expression. BRD4 loading at enhancers has been suggested to mediate pause-release and underlie the selective
NIAID Data Ecosystem90
Transcriptional responses to interferon require Mediator kinase-dependent pause release and mechanistically distinct functions of CDK8 and CDK19
Transcriptional responses to external stimuli remain poorly understood. Using GRO-Seq and PRO-Seq, we show that CDK8 kinase activity promotes RNA polymerase II (RNAPII) pause release in response to IF
NIAID Data Ecosystem70
