Formulation of Lozenge of Methanol Root Extract of Moringa oleifera Lam (Moringaceae) and its Efficacy against some Clinically isolated Pathogens

Background: This research aimed to determine the antimicrobial activities of the methanol root extract of Moringa oleifera and its lozenge formulation against the clinically isolated cultures of Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa using established procedures.

Method: The extract-formulated lozenges are 500 mg each, for five granule batches using the wet granulation method. The flow properties of the granules and tablet properties were evaluated using standard methods. The antimicrobial properties of the extract and the formulated lozenges batches A, B, C, D, and E were evaluated using a pour plate and Agar-well diffusion method respectively.

 Results: The evaluation of the granules and tablets met the required standards and the organisms were susceptible to the extract at concentrations of 200mg/ml, 100mg/ml, 50mg/ml, 25mg/ml, and 12.5mg/ml. The excipients had no significant effect on the antimicrobial activity of the extract-formulated lozenges batches B, C, D, and E. Batch A which contained no extract, showed no activity as negative control.

Conclusion: The results confirmed the effectiveness of the methanol root extract of M. oleifera formulated as lozenges against the examined organisms. Hence, this plant can be used in the formulation of lozenges and retain its activities in the treatment of mouth and upper respiratory tract infections.