Electronic NMR DATA from Synthesis of 4-substituted ethers of benzophenone and their antileishmanial activities

Leishmaniasis is a vector-borne protozoan disease, it is mainly originated from the bite of sandfly and initiated when parasite is transmitted to human at metacyclic flagellated promastigote form. In the current study, a synthesis of a series of 4-substituted benzophenone ethers <b>1–20</b> was carried out in good yields and their <i>in vitro</i> antileishmanial activities were also screened. Among synthetic derivatives, 15 compounds <b>1</b>, <b>3</b>, <b>5–12</b>, <b>15</b> and <b>17</b>–<b>20</b> showed antileishmanial activities against promastigotes of <i>Leishmania major</i> with IC₅₀ values in the range of 1.19–82.30 µg ml⁻¹, and the values were compared with those of the standard pentamidine (IC₅₀= 5.09 ± 0.09 µg ml⁻¹). Our study identified a series of new antileishmanial molecules as potential lead. Structures of these synthetic compounds were deduced by different spectroscopic techniques, such as ¹H-NMR, ¹³C-NMR, EI-MS, HREI-MS and IR.