Number of active compounds (N) detected in each screen for total number detected (unfiltered), number after drug like filtering (filtered.drug-like), hits from the LOPAC and Kinase libraries, and the

NIAID Data Ecosystem50

Discovery of reversible selective MAO-B inhibitors with anti-AChE activity derived from 4-oxo-N, 4-diphenyl butanamides - Supplementary Material

神经退行性疾病药物

抑制剂筛选

Table S1. Docking results of 4-oxo-N, 4-diphenyl butanamides against AChE, and MAOs. Table S2. Calculated physiochemical descriptors of 4-oxo-N, 4-diphenyl buta

DataCite Commons2024-05-17 更新30

CGP60474 KINOMEscan

抑制剂筛选

药物靶点发现

The KINOMEscan assay platform is based on a competition binding assay that is run for a compound of interest against each of a panel of 317 to 456 kinases. The assay has three components: a kinase-tag

NIAID Data Ecosystem50

U2OS cell line -SpCas9 inhibitor- Raw sequence reads

CRISPR-Cas9基因编辑

抑制剂筛选

To detect the cleavage activity of SpCas9 in U2OS after treat with small molecular inhibitor of SpCas9

NIAID Data Ecosystem30