U12-type introns were originally recognized based on their highly conserved non-consensus AT-AC termini1,2, which are spliced by a separate minor spliceosome3,4. Padgett and Krainer groups later showe

NIAID Data Ecosystem20

Minor splicing factor 65K/RNPC3 interacts with ANKRD11 and mediates HDAC3-regulated histone deacetylation and transcription

表观遗传调控

次要剪接体功能

Pre-mRNA splicing is coupled with DNA- and other RNA-processing machineries in the nucleus to form multilayer networks for accurate regulation of gene expression. However, those established couplings

NIAID Data Ecosystem20

p53 ablation fails to completely rescue microcephaly caused by impaired minor intron splicing. p53 ablation fails to completely rescue microcephaly caused by impaired minor intron splicing

发育疾病机制

次要剪接体功能

Mutations in the minor spliceosome components such as RNU4atac, a small nuclear RNA (snRNA), are linked to primary microcephaly. We have reported that in the conditional knockout (cKO) mice for Rnu11,

NIAID Data Ecosystem20

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.

次要剪接体功能

肿瘤遗传学

Most metazoans contain two distinct pre-mRNA splicing machineries: the major spliceosome, which removes >99% of introns, and the minor spliceosome, which recognizes <1% of introns. Despite their rarit

NIAID Data Ecosystem20

Genome wide mapping of effects of U6atac knockdown on pre-mRNA splicing

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