Table S1 - Two Years after Molecular Diagnosis of Familial Hypercholesterolemia: Majority on Cholesterol-Lowering Treatment but a Minority Reaches Treatment Goal

Potency scoring for several cholesterol-lowering drugs. *Potency scores for statins were derived from Walma Ned Tijdschr Geneeskd 2006;150:18–23, who based the scores themselves on Law BMJ 2003;326:1423-7. #Correction factor for ezetimibe was based on 17% additional decrease in LDL-C (100%/(100%-17%) = 1.20) when added to statins (Kastelein NEJM 2008; 358: 1431-43). Our study population used relative low doses of bile acid sequestrants and these were estimated to have only a modest effect on LDL-C levels. Even lower potency scores were applied for fibrates and nicotinic acid, which influence primarily triglyceride and HDL-cholesterol levels respectively and have a modest effect on LDL-C levels (Huijgen Expert Rev Cardiovasc Ther 2008;6:567-81).
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