Data from: Organ-specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides
收藏DataCite Commons2026-02-17 更新2026-04-25 收录
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https://datadryad.org/dataset/doi:10.5061/dryad.3xsj3txw1
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资源简介:
This dataset supports the manuscript “Organ-specific redox imbalance in
spinal muscular atrophy mice and partial rescue by SMN antisense
oligonucleotides” submitted to FEBS Letters. It contains raw and processed
experimental data generated to investigate tissue-specific redox
alterations and lipid peroxidation in a spinal muscular atrophy (SMA)
mouse model and following treatment with SMN antisense oligonucleotides.
The dataset includes uncropped raw Western blot images corresponding to
all main and supplementary figures, quantitative values used for graphical
representation and statistical analysis, and raw and processed lipid
peroxidation (MDA/TBARS) measurements obtained using a TECAN plate reader.
Processed data include blank correction, standard-curve-based conversion
to MDA equivalents, normalization to protein content, dilution correction,
and final normalization as used for figure generation in GraphPad Prism.
All files are organized by figure and assay type, with detailed README
documentation and processing notes provided to enable full reproducibility
and reuse. This dataset may be reused for independent reanalysis,
methodological comparison, or meta-analyses of redox regulation and
oxidative stress in neuromuscular disease models.
提供机构:
Dryad
创建时间:
2026-02-17



