Acute megakaryoblastic leukemia of Down syndrome (DS-AMKL) is a model of clonal evolution from a preleukemic transient myeloproliferative disorder requiring both a trisomy 21 (T21) and a GATA1s mutati

NIAID Data Ecosystem60

Generation of diffuse intrinsic pontine glioma mouse models by brainstem targeted in utero electroporation

脑肿瘤研究

基因编辑技术

Diffuse intrinsic pontine gliomas (DIPGs) are highly lethal childhood brain tumors. Their unique genetic makeup, pathological heterogeneity, and brainstem location all present challenges to treatment.

干细胞与再生医学数据中心2022-02-20 更新110

Chromosomal Manipulation by Site-Specific Recombinases and Fluorescent Protein-Based Vectors

基因编辑技术

疾病模型构建

Feasibility of chromosomal manipulation in mammalian cells was first reported 15 years ago. Although this technique is useful for precise understanding of gene regulation in the chromosomal context, a

NIAID Data Ecosystem70

human culture cell and mouse culture cell Targeted Locus (Loci)

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