Associations with CIMP-high in proximal and distal colorectal cancers.

Each multivariate logistic regression model assesses a variable of interest (stratified by tumor location in a given model), adjusting for all of the above remaining variables. An interaction was assessed by the likelihood ratio test that compares a model including a cross product term (of the location variable and another variable of interest) with a model excluding it.*��-catenin activation is defined as ��-catenin score ��3, where the ��-catenin score is the sum of nuclear (0, 1+ or 2+), cytoplasmic (0, 1+ or 2+) and membrane (0 or 1+) scores as originally described by Jass et al.[35].��Proximal colon includes cecum to transverse colon, and distal colon includes splenic flexure to rectum.#Because there was no CIMP-high ��-catenin-active tumors in distal colon, stable p for interaction and 95% CI for OR could not be estimated.CI, confidence interval; CIMP, CpG island methylator phenotype; LINE-1, long interspersed nucleotide element-1; MSI, microsatellite instability; OR, odds ratio.