HLA class II haplotypes in prediction of clustering of autoimmune diseases.

The results of multivariate models 1 and 2 with research questions: Do HLA class II haplotypes help to predict clustering of autoimmune diseases in children with multiple autoimmune diseases (Model 1), or in children from autoimmune families (Model 2). For Model 1, the statistics are: AIC for the confounding factors alone 470, AIC of this model 462, joint P value 0.0019. The joint P value concerns the effect of HLA class II genotypes. After model selection, Model 2 included only the confounding factors. HR = hazard ratio for the minor allele, CI = Confidence interval. Only children with information available on all covariates and were included in the analyses.