Risk ratios of FLG variants, allergic sensitization, and their combined effect on the occurrence of concurrent eczema at different ages.

RR: Risk ratio; CI: Confidence interval; WT: Wild-type; LOF: Loss-of-function; SPT −: Negative skin prick test; SPT +: Positive skin prick test.Combined genotypes of R501X, 2282del and S3247X variants; WT refers to individuals with wild-type genotypes for all three variants; LOF refers to individuals with a minor allele for at least one of the three variants.*All children are non-allergic (defined by negative skin prick test at the concurrent eczema assessment).†All children are wild type for FLG null variants.‡Children with both positive skin prick test and FLG LOF variants were compared to children with negative skin prick test and wild-type FLG.¶Association adjusted for gender.$Association adjusted for gender and age at follow-up.#The combined effect RR was estimated as: RR = exp(0.08+0.41+0.43).