Supplementary materials: Recommendations from Cochrane reviews for improving future trials on anesthesia and pain: a meta-research study

These are peer-reviewed supplementary materials for the article 'Recommendations from Cochrane reviews for improving future trials on anesthesia and pain: a meta-research study' published in the Journal of Comparative Effectiveness Research.Supplementary file 1: List of excluded studies with reasons for exclusionSupplementary file 2: Cochrane systematic reviews included in the studySupplementary file 3: Frequency of all categories of recommendationsSupplementary file 4: List of studies included in 'Trials of this type are not a priority / are unlikely' category, corresponding Cochrane Review Group, verbatim and categorization of reasons for their inclusionBackground: Cochrane systematic reviews (CSRs) have a section ‘Implications for research’ where authors make suggestions for improving future research. The authors of the present study assessed the prevalence and time dynamics of different recommendations in the CSRs about anesthesia and pain. Methods: The authors included all CSRs published by the Cochrane Anaesthesia Group and Cochrane Pain and Palliative Care Group before 17 July 2020. The authors analyzed recommendations for improving future research listed in the ‘Implications for research’ section of these CSRs and categorized recommendations for improvements. Results: They analyzed 370 reviews. Four categories of recommendations were present in more than 40% of the reviews. Most reviews recommended a larger sample size and better outcome choice, study design and choice of future intervention. These recommendations gradually increased in frequency in the Cochrane Pain and Palliative Care Group and mainly decreased in the Cochrane Anaesthesia Group. Conclusion: Recommendations from CSRs offer useful advice for trialists designing new trials.

本数据集为发表于《比较疗效研究杂志》的论文《基于Cochrane评论的麻醉和疼痛未来试验改进建议：一项元研究》的同行评审补充材料。补充文件1：排除研究的清单及其排除原因；补充文件2：纳入本研究中的Cochrane系统评价；补充文件3：所有类别建议的频率；补充文件4：不属于“此类试验不是优先事项/不太可能”类别的研究清单、相应的Cochrane评审小组、原因的文字描述及其分类。背景：Cochrane系统评价（CSRs）中设有“研究启示”部分，作者在此提出改进未来研究的建议。本研究作者评估了关于麻醉和疼痛的CSRs中不同建议的普遍性和时间动态。方法：作者纳入了Cochrane麻醉组和Cochrane疼痛与姑息治疗组在2020年7月17日之前发表的所有CSRs。作者分析了这些CSRs中“研究启示”部分所列的改进未来研究的建议，并对改进建议进行了分类。结果：分析了370篇评论。超过40%的评论中存在四种建议类别。大多数评论建议增加样本量并优化结果选择、研究设计和未来干预措施的选择。这些建议在Cochrane疼痛与姑息治疗组的频率逐渐增加，而在Cochrane麻醉组中则主要减少。结论：CSRs的建议为设计新试验的试验者提供了有用的建议。