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T-LBL may have its unique molecular biology, with high-frequency mutated genes detected in multiple signaling pathways.Our study showed that mediastinal offenders were more frequent in the Chinese population(70.8%),and the proportion of extranodal invasion was also higher（39.33%）probably related to a poor prognosis.Prognostic grouping combined with molecular biology features can facilitate more accurate identification of high-risk patients and develop better therapeutic strategies with new targeted agents.