Neutralizing antibody titers induced upon vaccination of mice with a pentavalent HPV L1 DNA vaccine.

Balb/c mice were vaccinated i.m. three times at two week intervals with a mixture of L1 vectors of HPV6, HPV16, HPV18, HPV26, and HPV51 (2 µg each), L1 vector of single HPV type (2 µg or 10 µg) utilizing electroporation. Gardasil vaccination was included as a positive control. Sera from 5 mice were pooled together, and in vitro neutralizing antibody titer (IVNT) was measured with HPV6, HPV16, HPV18, HPV26, and HPV51 PsVs. ND: Not detected at 1:50.