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GEF-H1-IRF5 mediated gene expression changes in BMDM by MDP recognition

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NIAID Data Ecosystem2026-03-11 收录
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The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKe Examination of MDP stimulated BMDM from WT, Arhgef2 and Irf5 KO mice

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2019-04-02
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