Absolute Stereochemical Determination of Asymmetric Sulfoxides via Central to Axial Induction of Chirality

The absolute configuration
of chiral sulfoxides is determined by
means of host–guest complexation that leads to the induction
of axial chirality in an achiral host. The central to axial induction
of helicity is rationalized by a simple recognition of the relative
length and size of the substituents attached to the S-center. This
technique is used to determine the absolute configuration of chiral
sulfoxides, requiring micrograms of sample, without the need for prefunctionalization.