Enteric neuronal GPR41-DHX9 signaling senses microbial metabolites to mediate the crosstalk between serotonergic neurons and intestinal stem cells [Ribo-seq]

We show that Dhx9 deficiency restricts the development and homeostasis of enteric neuron, and specifically suppresses the early development of serotonergic neurons. To investigate potential mechanisms whereby Dhx9 regulates the development and maturation of serotonin neuron,we performed Ribo-IP-seq analysis.