Transient shear wave elastometry using a portable magnetic resonance sensor

This repository contains all raw data files and processing scripts associated with the paper published in Magnetic Resonance in Medicine entitled “Transient Shear Wave Elastometry Using a Portable Magnetic Resonance Sensor.”

Abstract:

Purpose: Magnetic resonance elastography (MRE) provides detailed maps of tissue stiffness, helping to diagnose various health conditions, but requires the use of expensive clinical MRI scanners. Our approach utilizes compact, cost-effective portable MR sensors that offer bulk characterization of material properties in a region of interest close to the surface (within 1-2 cm). This accessible instrument could enable routine monitoring and prevention of diseases not readily evaluated with conventional tools.

Methods: The method was tested on tissue-mimicking phantoms with varying stiffness. The gels were excited with acoustic pulses (one cycle of a sinusoidal waveform) at a fixed distance from the MR sensor. A series of delays between acoustic excitation and MR signal detection allowed time for the pulse to travel to the sensitive region.

Results: The "arrival time" of the shear wave, determined by the time-dependent MR signal response, was used to calculate the shear wave speed. MR measurements of shear wave speed were compared with optical sensor measurements and manufacturer-tabulated values, aligning with expected relative differences between samples.

Conclusion: A portable MR-based transient elastometry technique for measuring tissue elasticity was developed and demonstrated on tissue-mimicking phantoms. Future improvements include using a new portable magnet to investigate depth-dependent changes in elasticity in stratified samples and integrating MR relaxation and diffusion measurements for comprehensive tissue analysis. This approach can complement conventional MRE in applications where a portable, affordable, and localized assessment of tissue stiffness is required.