Supplementary materials: Comparative efficacy and safety among high-intensity statins. Systematic Review and Meta-Analysis

These are peer-reviewed supplementary materials for the article 'Comparative efficacy and safety among high-intensity statins. Systematic Review and Meta-Analysis' published in the Journal of Comparative Effectiveness Research.Supplementary 1: Search StrategySupplementary 2: Study Characteristics Supplementary 3: Forest Plot for Subgroup Analysis of Studies Including ACS Patients Supplementary 4: Quality Assessment Aim: To summarize the evidence in terms of efficacy and safety of head-to-head studies of high-intensity statins regardless of the underlying population. Materials & methods: A systematic review and meta analysis was conducted to summarize the effect sizes in randomized controlled trials and cohort studies that compared high-intensity statins. Results: Based on 44 articles, similar effectiveness was observed across the statins in reducing LDL levels from baseline. All statins were observed to have similar adverse drug reactions (ADRs), although higher dosages were associated with more ADRs. Based on a pooled quantitative analysis of atorvastatin 80 mg versus rosuvastatin 40 mg, rosuvastatin was statistically more effective in reducing LDL. Conclusion: This review further confirms that high-intensity statins reduce LDL by ≥50%, favoring rosuvastatin over atorvastatin. Additional data are needed to confirm the clinical significance on cardiovascular outcomes using real-world studies.