MAVS and DDX58 interact
收藏reactome.org2025-01-09 收录
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https://reactome.org/PathwayBrowser/#/R-HSA-9833388
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Mitochondrial antiviral signaling protein (MAVS, IPS-1) acts as an adaptor linking RIG-I (also known as retinoic acid-inducible gene I protein RIG-1 or DExD/H-box helicase 58, DDX58) and MDA5 (IFIH1) to downstream molecules that activate TBK1 and IKKi (Kawai et al, 2005; Seth et al, 2005).
线粒体抗病毒信号蛋白(MAVS,IPS-1)充当适配器,将RIG-I(亦称视黄酸诱导基因I蛋白RIG-1或DExD/H框螺旋酶58,DDX58)与MDA5(IFIH1)连接至下游分子,从而激活TBK1和IKKi(Kawai等,2005;Seth等,2005)。
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