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A Novel and Highly Regioselective Route to Construct Methylthio-Substituted Pyridazines from Aryl Methyl Ketones at Room Temperature

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http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1290433
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资源简介:
A novel and highly regioselective two-step homocoupling/cyclization procedure from easily available aryl methyl ketones and hydrazine hydrate was developed for the synthesis of methylthio-substituted pyridazines at room temperature. The method has remarkable advantages owing to the simple substrates, mild reaction conditions, ease of manipulation, good yields and high ­regioselectivity.
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© Georg Thieme Verlag
创建时间:
2012-08-06
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