Crystal structure of the open conformation of insulin-regulated aminopeptidase in complex with a small-MW inhibitor

Crystal structure of the open conformation of insulin-regulated aminopeptidase in complex with a small-MW inhibitor Descriptor: 2-[2-(3,5-dimethylpyrazol-1-yl)-6-(4-methoxyphenyl)pyrimidin-4-yl]oxy-N-methyl-N-[(2-methylpyridin-3-yl)methyl]ethanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Mpakali, A, Giastas, P, Stratikos, E. Deposit date: 2023-05-10 Release date: 2024-09-04 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Stabilization of the open conformation omicron f insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor. Protein Sci., 33, 2024