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Development of an orally bioavailable SWI/SNF ATPase degrader and acquired mechanisms of resistance

NIAID Data Ecosystem2026-05-01 收录

靶向蛋白降解

药物耐药机制

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE250328 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2024-05-01

靶向蛋白降解

PROTAC

Proteolysis-targeting chimeras (PROTACs), heterobifunctional compounds that consist of protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic modality for ta

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Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design

靶向蛋白降解

计算机辅助药物设计

Targeted protein degradation by proteolysis-targeting chimera (PROTAC) is one of the exciting modalities for drug discovery and biological discovery. It is important to select an appropriate linker, a

NIAID Data Ecosystem80

Discovery of Novel Bifunctional Agents as Potent TRK Inhibitors and Degraders against xDFG Mutation Resistance

靶向蛋白降解

肿瘤药物研发

Despite the clinical success of tropomyosin receptor kinases (TRKs) inhibitors in NTRK fusion–positive cancers, prolonged administration has resulted in acquired resistance, particularly xDFG mutation

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SAM Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance

肿瘤靶向治疗

药物耐药机制

Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell c

NIAID Data Ecosystem90

Additional file 5: of PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs

多发性骨髓瘤靶向治疗

药物耐药机制

Table S4. EZH2i target genes are mostly bivalent in XG7 HMCLs (XLSX 10Â kb)

NIAID Data Ecosystem50